Attenuation Effect of Spinal Manipulation on Neuropathic and Postoperative Pain Through Activating Endogenous Anti-Inflammatory Cytokine Interleukin 10 in Rat Spinal Cord
Journal of Manipulative and Physiological Therapeutics
MDs, PhDs and DCs teamed up to investigate the roles that anti-inflammatory cytokine interleukin 10 (IL 10) and two proinflammatory cytokines have in the analgesic effects that spinal manipulation induces on neuropathic and postoperative pain. For this study, neuropathic and postoperative pain were mimicked by chronic compression and decompression of the dorsal root ganglion in adult rats. After chronic compression and decompression treatments, the rats exhibited behavioral and neurochemical signs of neuropathic pain. A chiropractic spinal manipulation tool called an activator-adjusting instrument was then used to deliver force to the spinous processes of L5 and L6. Repetitive activator-assisted spinal manipulative therapy significantly reduced simulated neuropathic and postoperative pain, inhibited or reversed neurochemical alterations, and increased anti-inflammatory IL-10 in the spinal cord. (This is a hyperlink to the abstract for «Attenuation Effect of Spinal Manipulation on Neuropathic and Postoperative Pain Through Activating Endogenous Anti-inflammatory Cytokine Interleukin 10 in Rat Spinal Cord.» To view the full article, you will need to log in to the journal’s website.) READ MORE
